The Rate of Bromate Decomposition in the Simulated Human Stomach and Associated Studies

In Part I, it expands the initial Phase I work by evaluating the roles of various co-constituents that could be present in drinking water or in stomach fluids to determine their affect on the rates of reaction in simulated gastric juice at low pH and in the presence of chloride and hydrogen sulfide. The issue being investigated was whether bromate could be decomposed to some degree in the stomach (and in other premetabolism segments such as liver and blood), and therefore reduce the amount that could ultimately reach target organs. If sufficient bromate could be reduced prior to reaching target organs, the actual risk at low environmentally relevant doses would be lower than predicted by the current risk calculation methodologies.